Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels.

ABSTRACT:

Importance

Low-density lipoprotein cholesterol (LDL-C) is typically estimated with the Friedewald or Martin/Hopkins equation; however, if triglyceride levels are 400 mg/dL or greater, laboratories reflexively perform direct LDL-C (dLDL-C) measurement. The use of direct chemical LDL-C assays and estimation of LDL-C via the National Institutes of Health Sampson equation are not well validated, and data on the accuracy of LDL-C estimation at higher triglyceride levels are limited.

Objective

To compare an extended Martin/Hopkins equation for triglyceride values of 400 to 799 mg/dL with the Friedewald and Sampson equations.

Design, setting, and participants

This cross-sectional study evaluated consecutive patients at clinical sites across the US with patient lipid distribu

SUBMITTER: Sajja A 

PROVIDER: S-EPMC8554644 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature