Platelet-derived sCD40L: specific inflammatory marker for early-stage severe acute respiratory syndrome coronavirus 2 infection.

ABSTRACT:

Background

The SARS-CoV-2 virus is the causing agent of the Coronavirus disease 2019 (COVID-19) characterized by a huge pro-inflammatory response and coagulation disorders that may lead to for its severe forms, in organ failure or even death. As major players of thrombo-inflammation, platelets release large amounts of immunomodulatory molecules and regulate leukocyte and endothelial activity, which are both altered in COVID-19. Altogether, this makes platelets a very likely actor of the thrombo-inflammatory complications of COVID-19. Thus, we propose to identify a platelet inflammatory signature of severe COVID-19 specifically modulated throughout the course of the disease.

Methods

Luminex technology and enzyme-linked immunosorbent assay were used to assess plasma levels of

SUBMITTER: Hamzeh-Cognasse H 

PROVIDER: S-EPMC8554745 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature