Insights from Leishmania (Viannia) guyanensis in vitro behavior and intercellular communication.

ABSTRACT:

Background

Pentavalent antimonial-based chemotherapy is the first-line approach for leishmaniasis treatment and disease control. Nevertheless antimony-resistant parasites have been reported in some endemic regions. Treatment refractoriness is complex and is associated with patient- and parasite-related variables. Although amastigotes are the parasite stage in the vertebrate host and, thus, exposed to the drug, the stress caused by trivalent antimony in promastigotes has been shown to promote significant modification in expression of several genes involved in various biological processes, which will ultimately affect parasite behavior. Leishmania (Viannia) guyanensis is one of the main etiological agents in the Amazon Basin region, with a high relapse rate (approximately 25%).

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SUBMITTER: Pereira LOR 

PROVIDER: S-EPMC8554959 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature