The role of MORC3 in silencing transposable elements in mouse embryonic stem cells.

ABSTRACT:

Background

Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been implicated in developmental disease and multiple cancers. Specifically, mammalian MORC3 mutations are associated with immune system defects and human cancers such as bladder, uterine, stomach, lung, and diffuse large B cell lymphomas. While previous studies have shown that MORC3 binds to H3K4me3 in vitro and overlaps with H3K4me3 ChIP-seq peaks in mouse embryonic stem cells, the mechanism by which MORC3 regulates gene expression is unknown.

Results

In this study, we identified that mutation in Morc3 results in a suppressor of variegation phenotype in a Modifier

SUBMITTER: Desai VP 

PROVIDER: S-EPMC8555065 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature