Genome-wide association study reveals 14 new SNPs and confirms two structural variants highly associated with the horned/polled phenotype in goats.

ABSTRACT:

Background

There is a long-term interest in investigating the genetic basis of the horned/polled phenotype in domestic goats. Here, we report a genome-wide association study (GWAS) to detect the genetic loci affecting the polled phenotype in goats.

Results

We obtained a total of 13,980,209 biallelic SNPs, using the genotyping-by-sequencing data from 45 Jintang Black (JT) goats, which included 32 female and nine male goats, and four individuals with the polled intersex syndrome (PIS). Using a mixed-model based GWAS, we identified two association signals, which were located at 150,334,857-150,817,260 bp (P = 5.15 × 10^- 119) and 128,286,704-131,306,537 bp (P = 2.74 × 10^- 15) on chromosome 1. The genotype distributions of the 14 most significantly associate

SUBMITTER: Guo J 

PROVIDER: S-EPMC8555091 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature