RNA-Seq analysis in giant pandas reveals the differential expression of multiple genes involved in cataract formation.

ABSTRACT:

Background

The giant panda (Ailuropoda melanoleuca) is an endangered mammalian species native to China. Fewer than 2500 giant pandas are known to exist, many of which are bred in captivity as a means to preserve and repopulate the species. Like other captive mammals, giant pandas acquire age-related cataracts, reducing their quality of life. Recent comparative genome-wide methylation analysis revealed 110 differentially methylated genes associated with cataract formation including six also associated with the formation of age-related cataracts in humans.

Results

To investigate the pathological pathway in greater detail, here we used RNA-Seq analysis to investigate the differential expression profiles of genes in three giant pandas with cataracts and three healthy controls. W

SUBMITTER: You Y 

PROVIDER: S-EPMC8555103 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature