Association between cardiometabolic disease multimorbidity and all-cause mortality in 2 million women and men registered in UK general practices.

ABSTRACT:

Background

Myocardial infarction (MI), stroke and diabetes share underlying risk factors and commonalities in clinical management. We examined if their combined impact on mortality is proportional, amplified or less than the expected risk separately of each disease and whether the excess risk is explained by their associated comorbidities.

Methods

Using large-scale electronic health records, we identified 2,007,731 eligible patients (51% women) and registered with general practices in the UK and extracted clinical information including diagnosis of myocardial infarction (MI), stroke, diabetes and 53 other long-term conditions before 2005 (study baseline). We used Cox regression to determine the risk of all-cause mortality with age as the underlying time variable and tested f

SUBMITTER: Canoy D 

PROVIDER: S-EPMC8555122 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature