The impact of blood transcriptomic biomarker targeted tuberculosis preventive therapy in people living with HIV: a mathematical modelling study.

ABSTRACT:

Background

Tuberculosis (TB) preventive therapy is recommended for all people living with HIV (PLHIV). Despite the elevated risk of TB amongst PLHIV, most of those eligible for preventive therapy would never develop TB. Tests which can identify individuals at greatest risk of disease would allow more efficient targeting of preventive therapy.

Methods

We used mathematical modelling to estimate the potential impact of using a blood transcriptomic biomarker (RISK11) to target preventive therapy amongst PLHIV. We compared universal treatment to RISK11 targeted treatment and explored the effect of repeat screening of the population with RISK11.

Results

Annual RISK11 screening, with preventive therapy provided to those testing positive, could avert 26% (95% CI 13-34) more c

SUBMITTER: Sumner T 

PROVIDER: S-EPMC8555196 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature