Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer.

ABSTRACT:

Background

Ferroptosis, a new form of programmed cell death, has great potential for cancer treatment. However, the roles of ferroptosis-related (FR) genes in breast cancer (BC) remain elusive.

Materials and methods

Using TCGA database, a novel FR risk signature was constructed through the Lasso regression analysis. Meanwhile, its prognostic value was assessed by a series of survival analyses. Besides, a nomogram was constructed to predict the overall survival rate (OSR) of individual at 1,3,5 year. Four validation cohorts (n = 2248), including METABRIC, GSE58812, GSE20685 and ICGC-KR datasets, were employed to test the prognostic value of FR risk signature. The effects of FR risk signature on BC immune microenvironment were explored by CIBERSORT algorithm and ssGSEA method.

SUBMITTER: Tang W 

PROVIDER: S-EPMC8555209 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature