Centrality of drug targets in protein networks.

ABSTRACT:

Background

In the pharmaceutical industry, competing for few validated drug targets there is a drive to identify new ways of therapeutic intervention. Here, we attempted to define guidelines to evaluate a target's 'fitness' based on its node characteristics within annotated protein functional networks to complement contingent therapeutic hypotheses.

Results

We observed that targets of approved, selective small molecule drugs exhibit high node centrality within protein networks relative to a broader set of investigational targets spanning various development stages. Targets of approved drugs also exhibit higher centrality than other proteins within their respective functional class. These findings expand on previous reports of drug targets' network centrality by suggesting so

SUBMITTER: Viacava Follis A 

PROVIDER: S-EPMC8555226 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature