Drivers of methicillin-resistant Staphylococcus aureus (MRSA) lineage replacement in China.

ABSTRACT:

Background

Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen subdivided into lineages termed sequence types (STs). Since the 1950s, successive waves of STs have appeared and replaced previously dominant lineages. One such event has been occurring in China since 2013, with community-associated (CA-MRSA) strains including ST59 largely replacing the previously dominant healthcare-associated (HA-MRSA) ST239. We previously showed that ST59 isolates tend to have a competitive advantage in growth experiments against ST239. However, the underlying genomic and phenotypic drivers of this replacement event are unclear.

Methods

Here, we investigated the replacement of ST239 using whole-genome sequencing data from 204 ST239 and ST59 isolates collected in C

SUBMITTER: Chen H 

PROVIDER: S-EPMC8555231 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature