Neutrophil-mediated clinical nanodrug for treatment of residual tumor after focused ultrasound ablation.

ABSTRACT:

Background

The risk of local recurrence after high-intensity focused ultrasound (HIFU) is relatively high, resulting in poor prognosis of malignant tumors. The combination of HIFU with traditional chemotherapy continues to have an unsatisfactory outcome because of off-site drug uptake.

Results

Herein, we propose a strategy of inflammation-tendency neutrophil-mediated clinical nanodrug targeted therapy for residual tumors after HIFU ablation. We selected neutrophils as carriers and PEGylated liposome doxorubicin (PLD) as a model chemotherapeutic nanodrug to form an innovative cell therapy drug (PLD@NEs). The produced PLD@NEs had a loading capacity of approximately 5 µg of PLD per 10⁶ cells and maintained the natural characteristics of neutrophils. The targeting per

SUBMITTER: Shen J 

PROVIDER: S-EPMC8555249 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature