Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer's disease.

ABSTRACT:

Objective

Until now, observational studies have explored the impact of vitamin C intake on Alzheimer's disease (AD) risk, however, reported ambiguous findings. To develop effective therapies or prevention, the causal link between vitamin C levels and AD should be established.

Methods

Here, we selected 11 plasma vitamin C genetic variants from a large-scale plasma vitamin C GWAS dataset (N = 52,018) as the potential instrumental variables. We extracted their corresponding summary statistics from large-scale IGAP clinically diagnosed AD GWAS dataset (N = 63,926) and UK Biobank AD proxy phenotype GWAS dataset (N = 314,278), as well as two UK Biobank subgroups including the maternal AD group (27,696 cases of maternal AD and 260,980 controls) and paternal AD group (14,338 cases o

SUBMITTER: Liu H 

PROVIDER: S-EPMC8555275 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature