Estrogen receptor-positive breast cancer survival prediction and analysis of resistance-related genes introduction.

ABSTRACT:

Background

In recent years, ER+ and HER2- breast cancer of adjuvant therapy has made great progress, including chemotherapy and endocrine therapy. We found that the responsiveness of breast cancer treatment was related to the prognosis of patients. However, reliable prognostic signatures based on ER+ and HER2- breast cancer and drug resistance-related prognostic markers have not been well confirmed, This study in amied to establish a drug resistance-related gene signature for risk stratification in ER+ and HER2- breast cancer.

Methods

We used the data from The Cancer Genoma Atlas (TCGA) breast cancer dataset and gene expression database (Gene Expression Omnibus, GEO), constructed a risk profile based on four drug resistance-related genes, and developed a nomogram to predict

SUBMITTER: Shuai C 

PROVIDER: S-EPMC8555508 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature