Activation of epigenetic regulator KDM6B by Salmonella Typhimurium enables chronic infections.

ABSTRACT: Non-typhoidal Salmonella (NTS) infections result in self limiting gastroenteritis except in rare cases wherein manifestations of chronic infections can occur. Strategies employed by Salmonella to thrive in hostile environments of host during chronic infections are complex and multifaceted. In chronic state, a coordinated action of bacterial effectors allows reprogramming of macrophages to M2 subtype and thereby creating a permissible replicative niche. The mechanistic details of these processes are not fully known. In the current study we identified, histone H3-lysine 27 trimethylation (H3K27me3)-specific demethylase, KDM6B to be upregulated in both cell culture and in murine model of Salmonella infection. KDM6B recruitment upon infection exhibited an associated loss o

SUBMITTER: Rana S 

PROVIDER: S-EPMC8555538 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature