Conductance stability and Na+ interaction with Shab K+ channels under low K+ conditions.

ABSTRACT: K⁺ ions exert a structural effect that brings stability to K⁺ selective pores. Thus, upon bathing Shab channels in 0 K⁺ solutions the ion conductance, G_K, irreversibly collapses. Related to this, studies with isolated KcsA channels have suggested that there is a transition [K⁺] around which the pore takes one of two conformations, either the low (non-conducting) or high K⁺ (conducting) crystal structures. We examined this premise by looking at the K⁺-dependency of G_K stability of Shab channels within the cell membrane environment. We found that: K⁺ effect on G_K stability is highly asymmetrical, and that as internal K⁺ is replaced by Na⁺ G_K drops in

SUBMITTER: Gomez-Lagunas F 

PROVIDER: S-EPMC8555546 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature