Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality.

ABSTRACT:

Rationale

Although there has been a long-standing interest in the human health effects of vitamin E, a comprehensive analysis of the association between circulating vitamin E and long-term mortality has not been conducted.

Objective

Determine whether serum α-tocopherol (the predominant form of vitamin E) is related to long-term overall and cause-specific mortality and elucidate the dose-response relationships with better quantification of the associations.

Methods and results

We conducted a biochemical analysis of 29 092 participants in the ATBC Study (Alpha-Tocopherol, Beta-Carotene Cancer Prevention) that originally tested vitamin E and β-carotene supplementation. Serum α-tocopherol was measured at baseline using high-performance liquid chromatography, and during a

SUBMITTER: Huang J 

PROVIDER: S-EPMC8555690 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature