Distinct regions of the striatum underlying effort, movement initiation and effort discounting.

ABSTRACT: The ventral striatum is believed to encode the subjective value of cost-benefit options; however, this effect has notably been absent during choices that involve physical effort. Previous work in freely moving animals has revealed opposing striatal signals, with greater response to increasing effort demands and reduced responses to rewards requiring effort. Yet, the relationship between these conflicting signals remains unknown. Using functional magnetic resonance imaging with a naturalistic maze-navigation paradigm, we identified functionally segregated regions within the ventral striatum that separately encoded effort activation, movement initiation and effort discounting of rewards. In addition, activity in regions associated with effort activation and discounting oppositely predicted s

SUBMITTER: Suzuki S 

PROVIDER: S-EPMC8555699 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature