Ventilatory control instability as a predictor of persistent periodic breathing in preterm infants.

ABSTRACT:

Background

Periodic breathing (PB) is common in preterm infants. We aimed to characterize the contribution of ventilatory control instability to the presence and persistence of PB longitudinally.

Methods

Infants born between 28 and 32 weeks of gestation were studied using daytime polysomnography at: 32-36 weeks postmenstrual age (PMA) (N = 32), 36-40 weeks PMA (N = 20), 3 months corrected age (CA) (N = 18) and 6 months CA (N = 19). Loop gain, a measure of sensitivity of the ventilatory control system, was estimated by fitting a mathematical model to ventilatory patterns associated with spontaneous sighs.

Results

The time spent in PB decreased from 32-36 weeks PMA to 6 months CA (P = 0.005). Across all studies, studies with PB (N = 62) were associated with higher loop

SUBMITTER: Siriwardhana LS 

PROVIDER: S-EPMC8555736 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature