The limits of personalization in precision medicine: Polygenic risk scores and racial categorization in a precision breast cancer screening trial.

ABSTRACT: Population-based genomic screening is at the forefront of a new approach to disease prevention. Yet the lack of diversity in genome wide association studies and ongoing debates about the appropriate use of racial and ethnic categories in genomics raise key questions about the translation of genomic knowledge into clinical practice. This article reports on an ethnographic study of a large pragmatic clinical trial of breast cancer screening called WISDOM (Women Informed to Screen Depending On Measures of Risk). Our ethnography illuminates the challenges of using race or ethnicity as a risk factor in the implementation of precision breast cancer risk assessment. Our analysis provides critical insights into how categories of race, ethnicity and ancestry are being deployed in the production of

SUBMITTER: James JE 

PROVIDER: S-EPMC8555816 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature