Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.

ABSTRACT:

Background

The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation.

Methods

We systematically searched electronic databases to identify articles reporting the impact of sarcopenia on the prognosis of patients with HNC. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were extracted and pooled. HR according to treatment modality were estimated using random-effects models. Statistical analyses were carried out using the Comprehensive Meta-Analysis software.

Results

In total, 18 studies enrolling 3,233 patients were included. Sarcopenia was associated with poor OS in both sur

SUBMITTER: Takenaka Y 

PROVIDER: S-EPMC8555817 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature