Neuronal Cascades Shape Whole-Brain Functional Dynamics at Rest.

ABSTRACT: At rest, mammalian brains display remarkable spatiotemporal complexity, evolving through recurrent functional connectivity (FC) states on a slow timescale of the order of tens of seconds. While the phenomenology of the resting state dynamics is valuable in distinguishing healthy and pathologic brains, little is known about its underlying mechanisms. Here, we identify neuronal cascades as a potential mechanism. Using full-brain network modeling, we show that neuronal populations, coupled via a detailed structural connectome, give rise to large-scale cascades of firing rate fluctuations evolving at the same time scale of resting-state networks (RSNs). The ignition and subsequent propagation of cascades depend on the brain state and connectivity of each region. The largest casca

SUBMITTER: Rabuffo G 

PROVIDER: S-EPMC8555887 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature