The Metabolome of Carbapenem-Resistant Klebsiella pneumoniae Infection in Plasma.

ABSTRACT:

Aim

Carbapenem-resistant Klebsiella pneumoniae- (CR-Kp-) mediated infections represent a challenge for clinical practitioners due to their expanding prevalence in hospital environments and antibiotic resistance. However, few studies have shown metabolic changes of carbapenem-resistant Klebsiella pneumoniae and CR-Kp-negative patients, and relevant studies are urgently needed.

Methods

In this study, we comprehensively profile the metabolites of 20 CR-Kp-positive and 18 CR-Kp-negative patients in plasma by using 2D gas chromatography-time-of-flight mass spectrometry (GC×GC-TOFMS).

Results

We identified 58 metabolites that were carbapenem-resistant Klebsiella pneumoniae-associated. N-Acetyl glucosamine, butanedioic acid, and myoinositol play a signif

SUBMITTER: Wen Z 

PROVIDER: S-EPMC8556109 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature