Aggressive pursuit and utilization of non-ideal donor lungs does not compromise post-lung transplant survival.

ABSTRACT:

Background

Organ procurement organizations (OPOs) vary in willingness to pursue and utilize non-ideal donor lungs; implications of these practices for lung transplant (LTx) recipients remain unclear. We examined associations between OPO-level behavior toward non-ideal donors and post-LTx outcomes.

Methods

Adult lung donors and corresponding adult first-time LTx recipients in the 2008-2019 UNOS registry were included. Non-ideal donors had any of age > 50, smoking history ≥20 pack-years, PaO₂ /FiO₂ ratio ≤350, donation after circulatory death, or increased risk status. OPOs were classified as least, moderately, or most aggressive based on non-ideal donor pursuit, consent attainment, lung recovery, and transplantation. Post-transplant outcomes were compare

SUBMITTER: Halpern SE 

PROVIDER: S-EPMC8556224 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature