Ionizing radiation downregulates estradiol synthesis via endoplasmic reticulum stress and inhibits the proliferation of estrogen receptor-positive breast cancer cells.

ABSTRACT: Breast cancer is a major threat to women's health and estrogen receptor-positive (ER⁺) breast cancer exhibits the highest incidence among these cancers. As the primary estrogen, estradiol strongly promotes cellular proliferation and radiotherapy, as a standard treatment, exerts an excellent therapeutic effect on ER⁺ breast cancer. Therefore, we herein wished to explore the mechanism(s) underlying the inhibitory effects of radiation on the proliferation of ER⁺ breast cancer cells. We used the ER⁺ breast cancer cell lines MCF7 and T47D, and their complementary tamoxifen-resistant cell lines in our study. The aforementioned cells were irradiated at different doses of X-rays with or without exogenous estradiol. CCK8 and clone-formation assays were us

SUBMITTER: Yang P 

PROVIDER: S-EPMC8556230 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature