A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia.

ABSTRACT: While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent stem cell (iPSC)-derived astrocyte model to investigate the temporal patterns of astroglia differentiation during developmental stages critical for SCZ using RNA sequencing. The model generated astrocyte-specific gene expression patterns during differentiation that corresponded well to astroglia-specific expression signatures of in vivo cortical fetal development. Using this model we identified SCZ-specific expression dynamics, and found that SCZ-associated differentially expressed genes were significantly enriched in the medial prefrontal cortex, striatum, and temporal lob

SUBMITTER: Szabo A 

PROVIDER: S-EPMC8556332 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature