Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways.

ABSTRACT: Dopamine plays a central role in motivating and modifying behavior, serving to invigorate current behavioral performance and guide future actions through learning. Here we examine how this single neuromodulator can contribute to such diverse forms of behavioral modulation. By recording from the dopaminergic reinforcement pathways of the Drosophila mushroom body during active odor navigation, we reveal how their ongoing motor-associated activity relates to goal-directed behavior. We found that dopaminergic neurons correlate with different behavioral variables depending on the specific navigational strategy of an animal, such that the activity of these neurons preferentially reflects the actions most relevant to odor pursuit. Furthermore, we show that these motor correlates are translated to

SUBMITTER: Zolin A 

PROVIDER: S-EPMC8556349 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature