Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.

ABSTRACT: Precise control of gene expression during differentiation relies on the interplay of chromatin and nuclear structure. Despite an established contribution of nuclear membrane proteins to developmental gene regulation, little is known regarding the role of inner nuclear proteins. Here we demonstrate that loss of the nuclear scaffolding protein Matrin-3 (Matr3) in erythroid cells leads to morphological and gene expression changes characteristic of accelerated maturation, as well as broad alterations in chromatin organization similar to those accompanying differentiation. Matr3 protein interacts with CTCF and the cohesin complex, and its loss perturbs their occupancy at a subset of sites. Destabilization of CTCF and cohesin binding correlates with altered transcription and accelerated differen

SUBMITTER: Cha HJ 

PROVIDER: S-EPMC8556400 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature