Autophagy is induced and modulated by cholesterol depletion through transcription of autophagy-related genes and attenuation of flux.

ABSTRACT: Perturbations to cellular homeostasis, including reduction of the cholesterol level, induce autophagy, a self-digestion process of cellular constituents through an autophagosomal-lysosomal pathway. In accord with its function as a membrane organizer and metabolic sentinel, the cellular response to cholesterol depletion comprises multiple phenomena, including the activation of transcriptional responses, accumulation of reactive oxygen species (ROS), and activation of stress-related signaling pathways. However, the molecular mechanisms by which cholesterol depletion regulates autophagy and the putative involvement of transcriptional responses, ROS and/or stress-related signaling in autophagy regulation in this biological context are not fully understood. Here, we find that cholesterol deplet

SUBMITTER: Shapira KE 

PROVIDER: S-EPMC8556405 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature