Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression.

ABSTRACT: Heightened aggressive behavior is considered as one of the central symptoms of many neuropsychiatric disorders including autism, schizophrenia, and dementia. The consequences of aggression pose a heavy burden on patients and their families and clinicians. Unfortunately, we have limited treatment options for aggression and lack mechanistic insight into the causes of aggression needed to inform new efforts in drug discovery and development. Levels of proinflammatory cytokines in the periphery or cerebrospinal fluid were previously reported to correlate with aggressive traits in humans. However, it is still unknown whether cytokines affect brain circuits to modulate aggression. Here, we examined the functional role of interleukin 1β (IL-1β) in mediating individual differences in aggression us

SUBMITTER: Takahashi A 

PROVIDER: S-EPMC8556414 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature