Semi-quantitative measurements of chemokine receptor 4-targeted ⁶⁸Ga-pentixafor PET/CT in response assessment of Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma.

ABSTRACT:

Purpose

⁶⁸Ga-pentixafor PET/CT was reported to have a high sensitivity in detecting tumor involvement of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) in our previous study. We aimed to further investigate the semi-quantitative measurements of ⁶⁸Ga-pentixafor PET/CT in response assessment in WM/LPL.

Methods

Fifteen patients with WM/LPL were recruited in a prospective cohort study and underwent both ⁶⁸Ga-pentixafor and ¹⁸F-FDG PET/CT at baseline and post-treatment. PET/CT-based responses were analyzed with semi-quantitative assessments of metabolic tumor volume (MTV) and total lesions glycolysis/uptake (TLG_FDG and TLU_CXCR4), and the correlation between PET/CT-based response and clinical resp

SUBMITTER: Pan Q 

PROVIDER: S-EPMC8556471 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature