Hyperopia Is Not Causally Associated With a Major Deficit in Educational Attainment.

ABSTRACT:

Purpose

Hyperopia (farsightedness) has been associated with a deficit in children's educational attainment in some studies. We aimed to investigate the causality of the relationship between refractive error and educational attainment.

Methods

Mendelian randomization (MR) analysis in 74,463 UK Biobank participants was used to estimate the causal effect of refractive error on years spent in full-time education, which was taken as a measure of educational attainment. A polygenic score for refractive error derived from 129 genetic variants was used as the instrumental variable. Both linear and nonlinear (allowing for a nonlinear relationship between refractive error and educational attainment) MR analyses were performed.

Results

Assuming a linear relationship between refr

SUBMITTER: Plotnikov D 

PROVIDER: S-EPMC8556559 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature