Molecular and Cellular Dynamics of Aortic Aneurysms Revealed by Single-Cell Transcriptomics.

ABSTRACT: The aorta is highly heterogeneous, containing many different types of cells that perform sophisticated functions to maintain aortic homeostasis. Recently, single-cell RNA sequencing studies have provided substantial new insight into the heterogeneity of vascular cell types, the comprehensive molecular features of each cell type, and the phenotypic interrelationship between these cell populations. This new information has significantly improved our understanding of aortic biology and aneurysms at the molecular and cellular level. Here, we summarize these findings, with a focus on what single-cell RNA sequencing analysis has revealed about cellular heterogeneity, cellular transitions, communications among cell populations, and critical transcription factors in the vascular wall. We also revi

SUBMITTER: Li Y 

PROVIDER: S-EPMC8556647 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature