Long-term persistence of SARS-CoV-2 neutralizing antibody responses after infection and estimates of the duration of protection.

ABSTRACT:

Background

The duration of immunity in SARS-CoV-2 infected people remains unclear. Neutralizing antibody responses are the best available correlate of protection against re-infection. Recent studies estimated that the correlate of 50% protection from re-infection was 20% of the mean convalescent neutralizing antibody titre.

Methods

We collected sera from a cohort of 124 individuals with RT-PCR confirmed SARS-CoV-2 infections from Prince of Wales Hospital, Princess Margaret Hospital, Queen Elizabeth Hospital and Queen Mary Hospitals of the Hospital Authority of Hong Kong, for periods up to 386 days after symptom onset and tested these for antibody to SARS-CoV-2 using 50% virus plaque reduction neutralization tests (PRNT₅₀), surrogate neutralization tests and spike

SUBMITTER: Lau EH 

PROVIDER: S-EPMC8556690 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature