Identification and characterization of a 25-lncRNA prognostic signature for early recurrence in hepatocellular carcinoma.

ABSTRACT:

Background

Early recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC). Long non-coding RNAs (lncRNAs) are deeply involved in HCC prognosis. In this study, we aimed to establish a prognostic lncRNA signature for HCC early recurrence.

Methods

The lncRNA expression profile and corresponding clinical data were retrieved from total 299 HCC patients in TCGA database. LncRNA candidates correlated to early recurrence were selected by differentially expressed gene (DEG), univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses. A 25-lncRNA prognostic signature was constructed according to receiver operating characteristic curve (ROC). Kaplan-Meier and multivariate Cox regression analyses were used to evalua

SUBMITTER: Fu Y 

PROVIDER: S-EPMC8556945 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature