DNA methylation of the KLK8 gene in depression symptomatology.

ABSTRACT:

Background

Depression is a common, complex, and debilitating mental disorder estimated to be under-diagnosed and insufficiently treated in society. Liability to depression is influenced by both genetic and environmental risk factors, which are both capable of impacting DNA methylation (DNAm). Accordingly, numerous studies have researched for DNAm signatures of this disorder. Recently, an epigenome-wide association study of monozygotic twins identified an association between DNAm status in the KLK8 (neuropsin) promoter region and severity of depression symptomatology.

Methods

In this study, we aimed to investigate: (i) if blood DNAm levels, quantified by pyrosequencing, at two CpG sites in the KLK8 promoter are associated with depression symptomatology and depression diagnosi

SUBMITTER: Starnawska A 

PROVIDER: S-EPMC8556955 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature