Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway.

ABSTRACT:

Background

Decidualization is essential to the successful pregnancy in mice. The molecular mechanisms and effects of Aurora kinase A (Aurora A) remain poorly understood during pregnancy. This study is the first to investigate the expression and role of Aurora A during mouse decidualization.

Methods

Quantitative real time polymerase chain reaction, western blotting and in situ hybridization were used to determine the expression of Aurora A in mouse uteri. Aurora A activity was inhibited by Aurora A inhibitor to explore the role of Aurora A on decidualization via regulating the Aurora A/Stat3/Plk1/Cdk1 signaling pathway.

Results

Aurora A was strongly expressed at implantation sites compared with inter-implantation sites. Furthermore, Aurora A was also significantly incr

SUBMITTER: Wang PC 

PROVIDER: S-EPMC8557062 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature