Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants.

ABSTRACT: Epilepsies of early childhood are frequently resistant to therapy and often associated with cognitive and behavioural comorbidity. Aetiology focused precision medicine, notably gene-based therapies, may prevent seizures and comorbidities. Epidemiological data utilizing modern diagnostic techniques including whole genome sequencing and neuroimaging can inform diagnostic strategies and therapeutic trials. We present a 3-year, multicentre prospective cohort study, involving all children under 3 years of age in Scotland presenting with epilepsies. We used two independent sources for case identification: clinical reporting and EEG record review. Capture-recapture methodology was then used to improve the accuracy of incidence estimates. Socio-demographic and clinical details were obtained at pre

SUBMITTER: Symonds JD 

PROVIDER: S-EPMC8557326 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature