Halogenation-Dependent Effects of the Chlorosulfolipids of Ochromonas danica on Lipid Bilayers.

ABSTRACT: The chlorosulfolipids are amphiphilic natural products with stereochemically complex patterns of chlorination and sulfation. Despite their role in toxic shellfish poisoning, potential pharmacological activities, and unknown biological roles, they remain understudied due to the difficulties in purifying them from natural sources. The structure of these molecules, with a charged sulfate group in the middle of the hydrophobic chain, appears incompatible with the conventional lipid bilayer structure. Questions about chlorosulfolipids remain unanswered partly due to the unavailability of structural analogues with which to conduct structure-function studies. We approach this problem by combining enantioselective total synthesis and membrane biophysics. Using a combination of Langmuir pressure-ar

SUBMITTER: Moss Iii FR 

PROVIDER: S-EPMC8557392 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature