Comparative Analysis of Mammal Genomes Unveils Key Genomic Variability for Human Life Span.

ABSTRACT: The enormous mammal's lifespan variation is the result of each species' adaptations to their own biological trade-offs and ecological conditions. Comparative genomics have demonstrated that genomic factors underlying both, species lifespans and longevity of individuals, are in part shared across the tree of life. Here, we compared protein-coding regions across the mammalian phylogeny to detect individual amino acid (AA) changes shared by the most long-lived mammals and genes whose rates of protein evolution correlate with longevity. We discovered a total of 2,737 AA in 2,004 genes that distinguish long- and short-lived mammals, significantly more than expected by chance (P = 0.003). These genes belong to pathways involved in regulating lifespan, such as inflammatory response and hemostasis

SUBMITTER: Farre X 

PROVIDER: S-EPMC8557403 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature