Independence estimators for re-randomisation trials in multi-episode settings: a simulation study.

ABSTRACT:

Background

Re-randomisation trials involve re-enrolling and re-randomising patients for each new treatment episode they experience. They are often used when interest lies in the average effect of an intervention across all the episodes for which it would be used in practice. Re-randomisation trials are often analysed using independence estimators, where a working independence correlation structure is used. However, research into independence estimators in the context of re-randomisation has been limited.

Methods

We performed a simulation study to evaluate the use of independence estimators in re-randomisation trials. We focussed on a continuous outcome, and the setting where treatment allocation does not affect occurrence of subsequent episodes. We evaluated different treatm

SUBMITTER: Kahan BC 

PROVIDER: S-EPMC8557515 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature