Clinical M2 macrophages-related genes to aid therapy in pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Increasing evidence supports that infiltration M2 Macrophages act as pivotal player in tumor progression of pancreatic ductal adenocarcinoma (PDAC). Nonetheless, comprehensive analysis of M2 Macrophage infiltration and biological roles of hub genes (FAM53B) in clinical outcome and immunotherapy was lack.

Method

The multiomic data of PDAC samples were downloaded from distinct datasets. CIBERSORT algorithm was performed to uncover the landscape of TIME. Weighted gene co-expression network analysis (WGCNA) was performed to identify candidate module and significant genes associated with M2 Macrophages. Kaplan-Meier curve and receiver operating characteristic (ROC) curves were applied for prognosis value validation. Mutation data was analyzed by using "maftools" R pack

SUBMITTER: Xu Q 

PROVIDER: S-EPMC8557582 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature