Methomyl-induced nephrotoxicity and protective effect of curcumin in male rats.

ABSTRACT: We investigated the ameliorative effect of the curcumin against methomyl-induced potential nephrotoxicity in Wistar albino male rats. In the present study, curcumin (100 mg kg^-1 bw), methomyl (0,8 mg kg^-1 bw) and methomyl plus curcumin were given to rats by oral for 28 days (for subacute examination). Concentrations of blood urea nitrogen, uric acid and creatinine in serum and malondialdehyde level and activities of antioxidant enzyme (superoxide dismutase, catalase, glutathione peroxidase and glutathione S transferase) and histopathological alterations in kidney tissues were studied. Methomyl caused an increment in the concentrations of blood urea nitrogen, creatinine, uric acid and MDA levels. In addition, methomyl caused a diminution in the activities of superoxide

SUBMITTER: Aslanturk A 

PROVIDER: S-EPMC8557666 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature