Genetic Determinants of Intrinsic Antibiotic Tolerance in Mycobacterium avium.

ABSTRACT: The Mycobacterium avium complex (MAC) is one of the most prevalent causes of nontuberculous mycobacteria pulmonary infection in the United States, and yet it remains understudied. Current MAC treatment requires more than a year of intermittent to daily combination antibiotic therapy, depending on disease severity. In order to shorten and simplify curative regimens, it is important to identify the innate bacterial factors contributing to reduced antibiotic susceptibility, namely, antibiotic tolerance genes. In this study, we performed a genome-wide transposon screen to elucidate M. avium genes that play a role in the bacterium's tolerance to first- and second-line antibiotics. We identified a total of 193 unique M. avium mutants with significantly altered susceptibility to at least one of t

SUBMITTER: Matern WM 

PROVIDER: S-EPMC8557931 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature