Ontology highlight
ABSTRACT:
SUBMITTER: Zalc A
PROVIDER: S-EPMC8557957 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zalc Antoine A Sinha Rahul R Gulati Gunsagar S GS Wesche Daniel J DJ Daszczuk Patrycja P Swigut Tomek T Weissman Irving L IL Wysocka Joanna J
Science (New York, N.Y.) 20210201 6529
During development, cells progress from a pluripotent state to a more restricted fate within a particular germ layer. However, cranial neural crest cells (CNCCs), a transient cell population that generates most of the craniofacial skeleton, have much broader differentiation potential than their ectodermal lineage of origin. Here, we identify a neuroepithelial precursor population characterized by expression of canonical pluripotency transcription factors that gives rise to CNCCs and is essential ...[more]