Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression.

ABSTRACT: Background: Obesity (OB) and major depressive disorder (MDD) are chronic conditions associated with disease burden, and their comorbidity appears more common among women. Mechanisms linking these conditions may involve inflammatory and metabolic pathways. The goal of this study was to evaluate the impact of MDD on relationships between OB and cardiometabolic function, and sex differences therein. Materials and Methods: Adult offspring from the New England Family Studies (NEFS) were assessed at ages 39-50, including anthropometry, cardiometabolic profile assays, and metabolic syndrome. Individuals were grouped by body mass index (BMI) and MDD status: healthy weight with (n = 50) or without MDD (n = 95) and obese with (n = 79) or without MDD (

SUBMITTER: Holsen LM 

PROVIDER: S-EPMC8558065 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature