Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in BRAF^V600E Papillary Thyroid Carcinoma.

ABSTRACT: Background: BRAF^V600E acts as an ATP-dependent cytosolic kinase. BRAF^V600E inhibitors are widely available, but resistance to them is widely reported in the clinic. Lipid metabolism (fatty acids) is fundamental for energy and to control cell stress. Whether and how BRAF^V600E impacts lipid metabolism regulation in papillary thyroid carcinoma (PTC) is still unknown. Acetyl-CoA carboxylase (ACC) is a rate-limiting enzyme for de novo lipid synthesis and inhibition of fatty acid oxidation (FAO). ACC1 and ACC2 genes encode distinct isoforms of ACC. The aim of our study was to determine the relationship between BRAF^V600E and ACC in PTC. Methods: We performed RNA-seq and DNA copy number analyses in PTC and

SUBMITTER: Valvo V 

PROVIDER: S-EPMC8558082 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature