Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review.

ABSTRACT:

Objectives

The early pathogenesis and precursors of Bipolar Disorder (BD) are poorly understood. There is some cross-sectional and retrospective evidence of affective lability as a predictor of BD, but this is subject to recall biases. The present review synthesises the prospective evidence examining affective lability and the subsequent development of BD at follow-up.

Methods

The authors performed a systematic search of PubMed, PsycInfo and Embase (1960-June 2020) and conducted hand searches to identify studies assessing affective lability (according to a conceptually-inclusive definition) at baseline assessment in individuals without a BD diagnosis, and a longitudinal follow-up assessment of bipolar (spectrum) disorders. Results are reported according to the PRISMA guideli

SUBMITTER: Taylor RH 

PROVIDER: S-EPMC8558129 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature