IFITM1 expression determines extracellular vesicle uptake in colorectal cancer.

ABSTRACT: The majority of colorectal cancer (CRC) patients carry mutations in the APC gene, which lead to the unregulated activation of the Wnt pathway. Extracellular vesicles (EV) are considered potential therapeutic tools. Although CRC is a genetically heterogeneous disease, the significance of the intra-tumor heterogeneity in EV uptake of CRC cells is not yet known. By using mouse and patient-derived organoids, the currently available best model of capturing cellular heterogeneity, we found that Apc mutation induced the expression of interferon-induced transmembrane protein 1 (Ifitm1), a membrane protein that plays a major role in cellular antiviral responses. Importantly, organoids derived from IFITM1^high CRC cells contained more proliferating cells and they had a markedly reduced upt

SUBMITTER: Kelemen A 

PROVIDER: S-EPMC8558170 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature