Subject-Specific Head Model Generation by Mesh Morphing: A Personalization Framework and Its Applications.

ABSTRACT: Finite element (FE) head models have become powerful tools in many fields within neuroscience, especially for studying the biomechanics of traumatic brain injury (TBI). Subject-specific head models accounting for geometric variations among subjects are needed for more reliable predictions. However, the generation of such models suitable for studying TBIs remains a significant challenge and has been a bottleneck hindering personalized simulations. This study presents a personalization framework for generating subject-specific models across the lifespan and for pathological brains with significant anatomical changes by morphing a baseline model. The framework consists of hierarchical multiple feature and multimodality imaging registrations, mesh morphing, and mesh grouping, which is shown to

SUBMITTER: Li X 

PROVIDER: S-EPMC8558307 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature